Identification of T-cell epitopes of SARS-coronavirus for development of peptide-based vaccines and cellular immunity assessment methods.
نویسندگان
چکیده
1. Subjects recovered from SARS-CoV infection retain memory of cellular immune response to epitopes spanning over a few regions of the viral nucleoprotein. Ten such epitopes were identified. 2. The majority of epitopes were predominantly recognised by CD8+ cytotoxic T cells and elicited persistent memory response lasting at least 2 years. 3. There is potential to use the nucleoprotein of SARSCoV to develop vaccines and diagnostic assays based on such cellular immune responses.
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ورودعنوان ژورنال:
- Hong Kong medical journal = Xianggang yi xue za zhi
دوره 17 Suppl 6 شماره
صفحات -
تاریخ انتشار 2011